Colloquium speaker, Justin Kinney (Cold Springs Harbor Lab) today at 3:45pm

[Patterson, Robin L.]

Please join us for the Physics Colloquium today, at 3:45 PM in The Robert Smith Seminar Room. There will be a reception at 3:30PM in the Atrium. Details concerning the talk are as follows:

Speaker:         Justin Kinney (Cole Springs Harbor Lab)
Date:               Tuesday, January 21, 2020
Time:              3:45PM
Place:             1080 Physics Research Building, The Robert Smith Seminar Room
Title:                Massively Parallel Assays, Machine Learning and the BioPhysics of Gene Regulation

Abstract: Gene expression in all organisms is controlled by short DNA and RNA sequences called cis-regulatory elements (CREs). Proteins in the cellular milieu bind to nucleic acid sequences present within CREs, interact with one another, and thus form macromolecular complexes that modulate the expression of nearby genes. My lab uses a combination of experiments and mathematical modeling to study the biophysics of these regulatory processes in living cells. Our experiments are based on massively parallel reporter assays, which leverage the power of ultra-high-throughput DNA sequencing to measure the effects that thousands to millions of different CRE sequence perturbations have on gene expression. Our mathematical modeling efforts aim to infer biophysical models from the large DNA sequence datasets that these experiments yield. This machine learning task has proven to be remarkably fertile from a theoretical standpoint, tying together ideas in Bayesian field theory, information theory, dimensionality reduction, and deep learning.

The website for the colloquium is https://physics.osu.edu/physics-colloquium-schedule


Also, there is the speaker/student discussion starting just after the colloquium, at 4:45pm in the Smith Seminar Room.



Robin
[The Ohio State University]
Robin Patterson
Program Coordinator
Department of Physics
1040K Physics Research Building, 191 W. Woodruff Avenue, Columbus, OH 43210
(614) 292-8523 Office     (614) 292-7557 Fax
patterson.716 at osu.edu<mailto:patterson.716 at osu.edu> osu.edu<http://osu.edu/>

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