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<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Please join us for the Physics Colloquium today, at<b> 3:45 PM</b> in The Robert Smith Seminar Room. There will be a reception at
<b>3:30PM</b> in the Atrium. Details concerning the talk are as follows: </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">Speaker</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif">: Justin Kinney (Cole Springs Harbor Lab)</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Date: Tuesday, January 21, 2020</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Time:
<b>3:45PM</b></span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Place: 1080 Physics Research Building, The Robert Smith Seminar Room</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Title: Massively Parallel Assays, Machine Learning and the BioPhysics of Gene Regulation<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Abstract: Gene expression in all organisms is controlled by short DNA and RNA sequences called cis-regulatory elements (CREs). Proteins in the cellular milieu bind to nucleic
acid sequences present within CREs, interact with one another, and thus form macromolecular complexes that modulate the expression of nearby genes. My lab uses a combination of experiments and mathematical modeling to study the biophysics of these regulatory
processes in living cells. Our experiments are based on massively parallel reporter assays, which leverage the power of ultra-high-throughput DNA sequencing to measure the effects that thousands to millions of different CRE sequence perturbations have on gene
expression. Our mathematical modeling efforts aim to infer biophysical models from the large DNA sequence datasets that these experiments yield. This machine learning task has proven to be remarkably fertile from a theoretical standpoint, tying together ideas
in Bayesian field theory, information theory, dimensionality reduction, and deep learning.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;font-family:"Helvetica",sans-serif;color:#555555"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">The website for the colloquium is
<a href="https://physics.osu.edu/physics-colloquium-schedule"><span style="color:#0563C1">https://physics.osu.edu/physics-colloquium-schedule</span></a></span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Also, there is the speaker/student discussion starting just after the colloquium, at 4:45pm in the Smith Seminar Room.</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:14.0pt;font-family:"Segoe Script";color:blue">Robin<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#0070C0"><img border="0" width="224" height="45" style="width:2.3333in;height:.4687in" id="Picture_x0020_1" src="cid:image001.png@01D5D037.C25867D0" alt="The Ohio State University"><o:p></o:p></span></p>
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<b><span style="font-size:9.0pt;font-family:"Helvetica",sans-serif;color:#BB0000;background:white">Robin Patterson</span></b><span style="font-size:9.0pt;font-family:"Helvetica",sans-serif;color:#333333"><br>
Program Coordinator<br>
</span><span style="font-size:9.0pt;font-family:"Helvetica",sans-serif;color:#BB0000;background:white">Department of Physics</span><span style="font-size:9.0pt;font-family:"Helvetica",sans-serif;color:#333333">
<br>
1040K Physics Research Building, 191 W. Woodruff Avenue, Columbus, OH 43210<br>
(614) 292-8523 Office (614) 292-7557 Fax<br>
</span><u><span style="font-size:9.0pt;font-family:"Helvetica",sans-serif;color:blue;background:white"><a href="mailto:patterson.716@osu.edu">patterson.716@osu.edu</a></span></u><span style="font-size:9.0pt;font-family:"Helvetica",sans-serif;color:#333333">
<a href="http://osu.edu/"><span style="color:blue;background:white">osu.edu</span></a>
<o:p></o:p></span></p>
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