Colloquium Speaker Zhen Yan today, Tuesday, October 2, 2012 at 4:00 PM

[Tate, Arnay]

Please take note of Colloquium taking place today, Tuesday, October 2, 2012 at 4:00 PM in The Robert Smith Seminar Room.  There will be a reception in the Atrium at 3:45 PM.  Details concerning the talk are as follows:


Speaker:               Zhen Yan - State University of New York at Buffalo

Date:                     Tuesday, October 2, 2012

Time:                    4:00 PM

Place:                    The Robert Smith Seminar Room
Title:                     " Dual Regulation of Glutamatergic Transmission and Cognition by Stress in Prefrontal Cortex"
Abstract:                Corticosterone, the major stress hormone, serves as a key controller for neuronal responses that underlie behavioral adaptation, as well as maladaptive changes that lead to cognitive and emotional disturbances in stress-related mental disorders. The molecular and cellular mechanisms underlying the complex actions of corticosteroid stress hormones are largely unknown. Here we demonstrate that acute vs. chronic stress exerts opposite effects on glutamatergic transmission in prefrontal cortex (PFC), which leads to opposing effects on PFC-dependent cognitive functions. Acute stress induces synaptic potentiation by increasing surface delivery of NMDA-type and AMPA-type glutamate receptor channels via glucocorticoid/SGK/Rab4 signaling, resulting in enhanced working memory performance. In contrast, repeated stress induces synaptic depression by increasing the ubiquitin/proteasome-mediated degradation of NMDA and AMPA receptor subunits, resulting in impaired recognition memory.



The website for the Colloquium is https://physics.osu.edu/physics-colloquium-schedule
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