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<p class="MsoPlainText"><span style="font-size:11.0pt">Please take note of Colloquium taking place today, Tuesday, October 2, 2012 at 4:00 PM in The Robert Smith Seminar Room. There will be a reception in the Atrium at 3:45 PM. Details concerning the talk
are as follows:<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Georgia","serif"">Speaker: Zhen Yan - State University of New York at Buffalo<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="font-size:11.0pt">Date: Tuesday, October 2, 2012<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="font-size:11.0pt">Time: 4:00 PM<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="font-size:11.0pt">Place: The Robert Smith Seminar Room<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Georgia","serif"">Title:
</span><span lang="EN" style="font-family:"Georgia","serif"">"</span><span lang="EN" style="font-family:"Georgia","serif"">
</span><span style="font-family:"Georgia","serif"">Dual Regulation of Glutamatergic Transmission and Cognition by Stress in Prefrontal Cortex</span><span lang="EN" style="font-family:"Georgia","serif"">"</span><span style="font-family:"Georgia","serif""><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Georgia","serif"">Abstract: Corticosterone, the major stress hormone, serves as a key controller for neuronal responses that underlie behavioral adaptation, as well as maladaptive changes that lead
to cognitive and emotional disturbances in stress-related mental disorders. The molecular and cellular mechanisms underlying the complex actions of corticosteroid stress hormones are largely unknown. Here we demonstrate that acute vs. chronic stress exerts
opposite effects on glutamatergic transmission in prefrontal cortex (PFC), which leads to opposing effects on PFC-dependent cognitive functions. Acute stress induces synaptic potentiation by increasing surface delivery of NMDA-type and AMPA-type glutamate
receptor channels via glucocorticoid/SGK/Rab4 signaling, resulting in enhanced working memory performance. In contrast, repeated stress induces synaptic depression by increasing the ubiquitin/proteasome-mediated degradation of NMDA and AMPA receptor subunits,
resulting in impaired recognition memory.<o:p></o:p></span></p>
<p style="margin:0in;margin-bottom:.0001pt;mso-add-space:auto"><span style="font-size:11.0pt;font-family:"Georgia","serif""><o:p> </o:p></span></p>
<p class="MsoPlainText"><span style="font-size:11.0pt">The website for the Colloquium is
</span><a href="https://physics.osu.edu/physics-colloquium-schedule"><span style="font-size:11.0pt">https://physics.osu.edu/physics-colloquium-schedule</span></a><span style="font-size:11.0pt">
<o:p></o:p></span></p>
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