Colloquium Speaker Michael Poirier today, Tuesday, November 1, 2011 at 4:00 PM

[Tate, Arnay]

Please take note of Colloquium taking place today, Tuesday, November 1, 2011, at 4:00 PM in The Robert Smith Seminar Room.  There will be a reception in the Atrium at 3:45 PM.  Details concerning the talk are as follows:



Speaker:              Michael Poirier - The Ohio State University

Date:                     Tuesday, November 1, 2011

Time:                    4:00 PM

Place:                    The Robert Smith Seminar Room

Title:                     The Mechanics of the Human Genome

Abstract:
Each of our cells contains 1 meter of DNA that is tightly wrapped to fit inside the ~5 micron wide nucleus of the cell. This highly condensed state of our DNA plays a central role in how the information in our genes is replicated, read and repaired. Yet, the mechanics by which the genome organization regulates the processing of DNA remains a mystery. I will discuss what is currently understood about the first level of genomic organization, the nucleosome - a 50 nm stretch of DNA tightly wrapped ~2 times around a protein core. Recent measurements from our group suggest how mechanical properties of our genome could regulate gene expression and DNA repair. I will also introduce the concepts of epigenetics and discuss how the physical properties of our genome (3-dimensional structure and folding) might provide a layer of genetic information that is directly inherited.

The website for the Colloquium is https://www.physics.ohio-state.edu/news/colloquium.php




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