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<p class="MsoPlainText">Please take note of Colloquium taking place today, Tuesday, November 1, 2011, at 4:00 PM in The Robert Smith Seminar Room. There will be a reception in the Atrium at 3:45 PM. Details concerning the talk are as follows:<o:p></o:p></p>
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<p class="MsoPlainText">Speaker: Michael Poirier – The Ohio State University<o:p></o:p></p>
<p class="MsoPlainText">Date: Tuesday, November 1, 2011<o:p></o:p></p>
<p class="MsoPlainText">Time: 4:00 PM<o:p></o:p></p>
<p class="MsoPlainText">Place: The Robert Smith Seminar Room<o:p></o:p></p>
<p class="MsoPlainText">Title: <span class="apple-style-span">
The Mechanics of the Human Genome</span><o:p></o:p></p>
<p class="MsoPlainText">Abstract: <o:p></o:p></p>
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<span style="font-size:10.5pt;font-family:"Georgia","serif"">Each of our cells contains 1 meter of DNA that is tightly wrapped to fit inside the ~5 micron wide nucleus of the cell. This highly condensed state of our DNA plays a central role in how the information
in our genes is replicated, read and repaired. Yet, the mechanics by which the genome organization regulates the processing of DNA remains a mystery. I will discuss what is currently understood about the first level of genomic organization, the nucleosome
- a 50 nm stretch of DNA tightly wrapped ~2 times around a protein core. Recent measurements from our group suggest how mechanical properties of our genome could regulate gene expression and DNA repair. I will also introduce the concepts of epigenetics and
discuss how the physical properties of our genome (3-dimensional structure and folding) might provide a layer of genetic information that is directly inherited. </span><span style="font-size:10.5pt;font-family:"Georgia","serif""><o:p></o:p></span></p>
<p class="MsoPlainText">The website for the Colloquium is <a href="https://www.physics.ohio-state.edu/news/colloquium.php">
https://www.physics.ohio-state.edu/news/colloquium.php</a><o:p></o:p></p>
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