[ACVM] coronavirus question

[Saif, Linda]

Hi Becky,
Please email paper from Japan and the summary article from Linda
Thanks,
Linda Saif

On 12/4/15 8:56 AM, "Wilkes, Rebecca Penrose" <beckpen at utk.edu> wrote:

>This is sounding more and more like Winter Dysentery, Dustin Loy. I have
>the paper from Japan if anyone wants it, just email me.
>Becky
>
>________________________________________
>From: Acvm_diplomates
><acvm_diplomates-bounces+beckpen=utk.edu at lists.osu.edu> on behalf of
>Woolums, Amelia <amelia.woolums at msstate.edu>
>Sent: Thursday, December 3, 2015 10:50 PM
>To: ACVM - The American College of Veterinary Microbiologists Listserv
>Cc: Linda D. Mittel
>Subject: Re: [ACVM] coronavirus question
>
>Thanks very much to all of you who have responded to my question about
>disease due to coronavirus in adult horses.  Dr. Ed Dubovi forwarded a
>message from Dr. Linda Mittel at Cornell who has experience with cases,
>and she gave me permission to post it on our listserv―see below.  Thanks,
>Dr. Mittel.
>
>ACVM Diplomates:  if you’d like a copy of the summary Dr. Mittel sent me,
>let me know and I’ll send it to you off the list.
>
>Amelia
>
>
>
>
>
>Dear Dr. Woolums,
>
>I wanted to address your questions on corona virus in horses.  I have
>been working with corona virus in horses for over 3 years.   We have seen
>a number of cases in horses in NY and also submission from many states.
>We consistently get positive  PCRs for the beta corona in the feces of
>horse with fevers, depression, gi upset  exhibited as anorexia, subtle to
>moderately severe colic, +/- diarrhea and in some cases hyperammonemia.
>The presentations show no signs of respiratory illness even though we
>have positive  PCRs from  nasal swabs in a small percentage of cases.
>Pusterla is publishing on this and percentages associated with clinically
>ill animals.  Some horses seem to become very ill and others no ill it
>appears although feces are positive by PCR.
>
>There is a paper published from japan of experimental challenge in horses
>and the clinical presentation, PCR results, etc.
>
>I do not have access to the published article at this time, but should be
>in pub med .  It was published in 2015 I believe.
>
>There will be a review article out in EVJ in the nearest future that was
>written by Pusterla, Vin, Divers, Mittel, and Leuttenegger.
>I am not sure when that is to be published.
>
>I have attached a summary I did for the Equine Communication Center
>disease work up page.
>Linda Mittel, MSPH, DVM
>Animal Health Diagnostic Center
>Cornell University
>607.253.3633
>
>--
>Amelia R. Woolums, DVM MVSc PhD DACVIM DACVM
>
>Professor
>Department of Pathobiology and Population Medicine
>College of Veterinary Medicine
>Mississippi State University
>Mississippi State, MS  39762
>cell: 706-206-8652
>
>
>
>
>On 12/3/15, 7:43 AM, "Acvm_diplomates on behalf of Wilkes, Rebecca
>Penrose" <acvm_diplomates-bounces at lists.osu.edu on behalf of
>beckpen at utk.edu> wrote:
>
>>Hi All,
>>
>>I have certainly seen coronavirus associated with foal diarrhea, but I
>>always wonder about coronavirus as a primary cause of disease in adult
>>animals. Is it possible that there is a "new" more virulent strain
>>circulating now in horses (like what we are seeing with coronaviruses in
>>humans- SARS and MERS). Has any phylogenetic evaluation been done on the
>>virus strains from the different adult cases?
>>
>> I know one study out of Japan tried to address experimental challenge in
>>draft horses (9-10 mo olds) but a big flaw I saw with the study is that
>>coronavirus positive feces was used instead of isolated virus for
>>challenge and it did not appear the horses were tested for coronavirus
>>RNA prior to the study, though they were tested for coronavirus
>>antibodies. Also no controls were used for the study.
>>
>>Just my two cents.
>>Becky Wilkes
>>
>>________________________________________
>>From: Acvm_diplomates
>><acvm_diplomates-bounces+beckpen=utk.edu at lists.osu.edu> on behalf of
>>Saif, Linda <saif.2 at osu.edu>
>>Sent: Wednesday, December 2, 2015 7:57 PM
>>To: ACVM - The American College of Veterinary Microbiologists Listserv
>>Subject: Re: [ACVM] coronavirus question
>>
>>Hi Amelia
>>We have pan coronavirus primers that we could use to test fecal samples
>>if someone wants to send them to me from the affected horses.
>>Regards
>>Linda Saif
>>saif.2 at osu.edu
>>
>>
>>Sent from my iPhone
>>
>>> On Dec 2, 2015, at 3:52 PM, Woolums, Amelia
>>><amelia.woolums at msstate.edu> wrote:
>>>
>>> Hello ACVM Diplomates,
>>>
>>> Have any of you been involved with evaluating cases of acute febrile
>>> disease +/- gastrointestinal signs in adult horses, with fecal
>>>coronavirus
>>> shedding identified in these horses?  There has been some discussion of
>>> such cases among veterinary internists I know, and I¹ve wondered what
>>>the
>>> vet microbiology community makes of this.  Basically I¹ve been a bit
>>> skeptical that coronavirus is the cause of these signs, but I¹ve never
>>> been directly involved with a case.  I also haven¹t found any reports
>>>of
>>> experimental challenge studies leading to typical disease in adult
>>>horses.
>>> Is anyone aware of such work?
>>>
>>> Thanks for any information.
>>>
>>> Amelia Woolums
>>>
>>>
>>> Amelia R. Woolums, DVM MVSc PhD DACVIM DACVM
>>>
>>> Professor
>>> Department of Pathobiology and Population Medicine
>>> College of Veterinary Medicine
>>> Mississippi State University
>>> Mississippi State, MS  39762
>>> cell: 706-206-8652
>>>
>>>
>>> _______________________________________________
>>> Acvm_diplomates mailing list
>>> Acvm_diplomates at lists.osu.edu
>>> https://lists.osu.edu/mailman/listinfo/acvm_diplomates
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