[ACVM] coronavirus question

[Wilkes, Rebecca Penrose]

This is sounding more and more like Winter Dysentery, Dustin Loy. I have the paper from Japan if anyone wants it, just email me.
Becky

________________________________________
From: Acvm_diplomates <acvm_diplomates-bounces+beckpen=utk.edu at lists.osu.edu> on behalf of Woolums, Amelia <amelia.woolums at msstate.edu>
Sent: Thursday, December 3, 2015 10:50 PM
To: ACVM - The American College of Veterinary Microbiologists Listserv
Cc: Linda D. Mittel
Subject: Re: [ACVM] coronavirus question

Thanks very much to all of you who have responded to my question about
disease due to coronavirus in adult horses.  Dr. Ed Dubovi forwarded a
message from Dr. Linda Mittel at Cornell who has experience with cases,
and she gave me permission to post it on our listserv―see below.  Thanks,
Dr. Mittel.

ACVM Diplomates:  if you’d like a copy of the summary Dr. Mittel sent me,
let me know and I’ll send it to you off the list.

Amelia





Dear Dr. Woolums,

I wanted to address your questions on corona virus in horses.  I have
been working with corona virus in horses for over 3 years.   We have seen
a number of cases in horses in NY and also submission from many states.
We consistently get positive  PCRs for the beta corona in the feces of
horse with fevers, depression, gi upset  exhibited as anorexia, subtle to
moderately severe colic, +/- diarrhea and in some cases hyperammonemia.
The presentations show no signs of respiratory illness even though we
have positive  PCRs from  nasal swabs in a small percentage of cases.
Pusterla is publishing on this and percentages associated with clinically
ill animals.  Some horses seem to become very ill and others no ill it
appears although feces are positive by PCR.

There is a paper published from japan of experimental challenge in horses
and the clinical presentation, PCR results, etc.

I do not have access to the published article at this time, but should be
in pub med .  It was published in 2015 I believe.

There will be a review article out in EVJ in the nearest future that was
written by Pusterla, Vin, Divers, Mittel, and Leuttenegger.
I am not sure when that is to be published.

I have attached a summary I did for the Equine Communication Center
disease work up page.
Linda Mittel, MSPH, DVM
Animal Health Diagnostic Center
Cornell University
607.253.3633

--
Amelia R. Woolums, DVM MVSc PhD DACVIM DACVM

Professor
Department of Pathobiology and Population Medicine
College of Veterinary Medicine
Mississippi State University
Mississippi State, MS  39762
cell: 706-206-8652




On 12/3/15, 7:43 AM, "Acvm_diplomates on behalf of Wilkes, Rebecca
Penrose" <acvm_diplomates-bounces at lists.osu.edu on behalf of
beckpen at utk.edu> wrote:

>Hi All,
>
>I have certainly seen coronavirus associated with foal diarrhea, but I
>always wonder about coronavirus as a primary cause of disease in adult
>animals. Is it possible that there is a "new" more virulent strain
>circulating now in horses (like what we are seeing with coronaviruses in
>humans- SARS and MERS). Has any phylogenetic evaluation been done on the
>virus strains from the different adult cases?
>
> I know one study out of Japan tried to address experimental challenge in
>draft horses (9-10 mo olds) but a big flaw I saw with the study is that
>coronavirus positive feces was used instead of isolated virus for
>challenge and it did not appear the horses were tested for coronavirus
>RNA prior to the study, though they were tested for coronavirus
>antibodies. Also no controls were used for the study.
>
>Just my two cents.
>Becky Wilkes
>
>________________________________________
>From: Acvm_diplomates
><acvm_diplomates-bounces+beckpen=utk.edu at lists.osu.edu> on behalf of
>Saif, Linda <saif.2 at osu.edu>
>Sent: Wednesday, December 2, 2015 7:57 PM
>To: ACVM - The American College of Veterinary Microbiologists Listserv
>Subject: Re: [ACVM] coronavirus question
>
>Hi Amelia
>We have pan coronavirus primers that we could use to test fecal samples
>if someone wants to send them to me from the affected horses.
>Regards
>Linda Saif
>saif.2 at osu.edu
>
>
>Sent from my iPhone
>
>> On Dec 2, 2015, at 3:52 PM, Woolums, Amelia
>><amelia.woolums at msstate.edu> wrote:
>>
>> Hello ACVM Diplomates,
>>
>> Have any of you been involved with evaluating cases of acute febrile
>> disease +/- gastrointestinal signs in adult horses, with fecal
>>coronavirus
>> shedding identified in these horses?  There has been some discussion of
>> such cases among veterinary internists I know, and I¹ve wondered what
>>the
>> vet microbiology community makes of this.  Basically I¹ve been a bit
>> skeptical that coronavirus is the cause of these signs, but I¹ve never
>> been directly involved with a case.  I also haven¹t found any reports of
>> experimental challenge studies leading to typical disease in adult
>>horses.
>> Is anyone aware of such work?
>>
>> Thanks for any information.
>>
>> Amelia Woolums
>>
>>
>> Amelia R. Woolums, DVM MVSc PhD DACVIM DACVM
>>
>> Professor
>> Department of Pathobiology and Population Medicine
>> College of Veterinary Medicine
>> Mississippi State University
>> Mississippi State, MS  39762
>> cell: 706-206-8652
>>
>>
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>> Acvm_diplomates at lists.osu.edu
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