[Intl_DxMedPhys] MUGA EF discrepancies?

[Nima Kasraie]

Hello group,

Need some collective wisdom from the hive:

What are possible causes of the automated software overestimating EF, compared to manual EF calculation in MUGA studies? Does anyone have any experience with this?

I have a case of discrepancy between the automated EF value generated by the Siemens analysis software and a manual calculation of the EF, where the auto-generated EF value seems to be much higher than the manually calculated EF obtained using:

Manual EF calculation formula used: EF = (EDC-ESC)/(EDC-bkg)

Using this formula, EF is ~ 67.8%, which falls within normal range and correlates well with the patient's prior echocardiogram showing an LVEF of 67%. However, the software is giving an EF value of 82.7%, which seems high.

Perhaps a software correction I’m not aware of?


Nima



P.S. : Interesting side note:

ChatGPT responded saying a low background count can give elevated EF values:

[cid:image004.png at 01DBC982.24F2E070]

which is actually false: EF goes down with decreased bkg counts (as one can see from the green formula above). And he’s using the same formula.

So there’s that. Ha!😊

And btw, Perplexity said the exact opposite:

[cid:image008.png at 01DBC982.24F2E070]


Moral of the story: your model is only as good as the sources you train it with!

Nima Kasraie, PhD, MSc, DABR (D), DABSNM (I)
Associate Professor of Radiology
Medical Physics Division

Department of Radiology
5323 Harry Hines Blvd., Dallas, Texas 75390-9071
Phone: 214-648-7978
https://urldefense.com/v3/__http://www.utsouthwestern.edu/radiology__;!!KGKeukY!25bfLAaxVTa-WLkAxQ_8HWNJaRXNj_RcF1yRTDrA0LM3YghSmtAuFFrteQA4M455_O0kbbCf9mCtlRJldwcg_FbJy8-vxMPGswuOyOiVdKzKtGzD2NBPJw$ <https://urldefense.com/v3/__http://www.utsouthwestern.edu/radiology__;!!KGKeukY!25bfLAaxVTa-WLkAxQ_8HWNJaRXNj_RcF1yRTDrA0LM3YghSmtAuFFrteQA4M455_O0kbbCf9mCtlRJldwcg_FbJy8-vxMPGswuOyOiVdKzKtGzD2NBPJw$ >

[cid:image001.png at 01DBC97F.660B0770]
[cid:image002.png at 01DBC97F.660B0770]


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