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<div><font color="#2F5496">Everyone, Reminder of this special seminar today from 11:00-12:00 in the Smith Conference Room, 1080 PRB. Thanks, Jenny</font></div>
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<div><font face="Calibri" size="2"><span style="font-size:11pt;"><b>From:</b> Finnell, Jenny
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<b>Sent:</b> Wednesday, May 1, 2019 5:41 PM<br>
<b>To:</b> physics-all@lists.osu.edu<br>
<b>Subject:</b> Special Seminar Friday, May 3, 11AM -Ming-Daw Tsai in 1080 PRB</span></font></div>
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<div><font face="Calibri">Please join us on Friday May 3, 11AM-12PM (1080 PRB) for a special seminar by Ming-Daw Tsai from Sinica Cryo-EM Center in Taiwan (and former OSU faculty). </font></div>
<div><font face="Calibri">Faculty Host: Prof. Dongping Zhong </font></div>
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<div style="text-align:center;"><font face="Roboto"><b>New Horizon in Enzymology from Cryo-EM and X-ray Free-electron Laser (XFEL)</b></font></div>
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<div style="text-align:center;"><font face="Roboto"><b>Ming-Daw Tsai</b>, Institute of Biological Chemistry, Academia Sinica</font></div>
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<div><font face="Roboto"><b>Abstract</b></font></div>
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<div style="text-indent:24pt;"><font face="Times New Roman">Structural determination of enzymes has been an integral part of mechanistic enzymology. However, the two common approaches, X-ray crystallography and NMR, can only be obtained at specific conditions,
whereas mechanistic analysis often covers a broad range of conditions. These limitations are being overcome by two emerging structural biology techniques: Cryo-EM can facilitate structural determination at multiple solution conditions with various intermediate
complexes, while XFEL allows determination of multiple intermediate structures at ultrashort time scale. This lecture will cover application of cryo-EM to the mechanism of ketol-acid reductoisomerase (KARI), and application of XFEL to the mechanism of a photolyase.</font></div>
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<div><font face="Roboto">Ming-Daw Tsai is a former faculty of OSU (1981-2007) and director of CCIC (1993-2007). He is now director of Taiwan Protein Project and Academia Sinica Cryo-EM Center.</font></div>
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<div><font face="Vladimir Script" color="#003399"><i>Jenny</i></font></div>
<div><font face="Calibri" size="2" color="#2F5496"><span style="font-size:10pt;"> <font face="Palatino Linotype">Jenny Finnell, </font><a href="mailto:finnell.2@osu.edu"><font face="Palatino Linotype" color="blue"><u>finnell.2@osu.edu</u></font></a><font size="2" color="black"><span style="font-size:11pt;">;
614-292-2403, Room M2031</span></font></span></font></div>
<div><font face="Palatino Linotype" size="2" color="#2F5496"><span style="font-size:10pt;">Assistant<font color="#525252"> to </font><b>Nuclear Physics Theory, High Energy Theory, Physics Education</b>, </span></font></div>
<div><font face="Palatino Linotype" size="2" color="#2F5496"><span style="font-size:10pt;"><b>Nuclear Physics Experiment,</b><font color="#525252"> </font><b>Molecular Biological Dynamics</b><font color="#525252"> and </font><b>Microwave</b><font color="#833C0B">
</font><font color="#525252">groups</font></span></font></div>
<div><font face="Palatino Linotype" size="2" color="#C00000"><span style="font-size:10pt;"><b><u>Physics Dept | Ohio State University</u></b><font color="#767171"><b><u> |</u></b></font><font color="red"> </font><font color="#7B7B7B"><b>191 W. Woodruff Ave,
Columbus, OH 43210</b></font></span></font></div>
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